Ontology highlight
ABSTRACT:
SUBMITTER: Adames NR
PROVIDER: S-EPMC2185533 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
Adames N R NR Oberle J R JR Cooper J A JA
The Journal of cell biology 20010401 1
The spindle position checkpoint in Saccharomyces cerevisiae delays mitotic exit until the spindle has moved into the mother-bud neck, ensuring that each daughter cell inherits a nucleus. The small G protein Tem1p is critical in promoting mitotic exit and is concentrated at the spindle pole destined for the bud. The presumed nucleotide exchange factor for Tem1p, Lte1p, is concentrated in the bud. These findings suggested the hypothesis that movement of the spindle pole through the neck allows Tem ...[more]