Ontology highlight
ABSTRACT:
SUBMITTER: Caydasi AK
PROVIDER: S-EPMC4091827 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Caydasi Ayse Koca AK Micoogullari Yagmur Y Kurtulmus Bahtiyar B Palani Saravanan S Pereira Gislene G
Molecular biology of the cell 20140521 14
In addition to their well-known role in microtubule organization, centrosomes function as signaling platforms and regulate cell cycle events. An important example of such a function is the spindle position checkpoint (SPOC) of budding yeast. SPOC is a surveillance mechanism that ensures alignment of the mitotic spindle along the cell polarity axis. Upon spindle misalignment, phosphorylation of the SPOC component Bfa1 by Kin4 kinase engages the SPOC by changing the centrosome localization of Bfa1 ...[more]