Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels.
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ABSTRACT:
SUBMITTER: Fischer-Lougheed J
PROVIDER: S-EPMC2192379 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Publications
Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels.
Fischer-Lougheed J J Liu J H JH Espinos E E Mordasini D D Bader C R CR Belin D D Bernheim L L
The Journal of cell biology 20010501 4
Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through alpha1H T channels. ...[more]
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