Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Menchaca AA
PROVIDER: S-EPMC2234144 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Rodríguez-Menchaca Aldo A AA Navarro-Polanco Ricardo A RA Ferrer-Villada Tania T Rupp Jason J Sachse Frank B FB Tristani-Firouzi Martin M Sánchez-Chapula José A JA
Proceedings of the National Academy of Sciences of the United States of America 20080123 4
Although chloroquine remains an important therapeutic agent for treatment of malaria in many parts of the world, its safety margin is very narrow. Chloroquine inhibits the cardiac inward rectifier K(+) current I(K1) and can induce lethal ventricular arrhythmias. In this study, we characterized the biophysical and molecular basis of chloroquine block of Kir2.1 channels that underlie cardiac I(K1). The voltage- and K(+)-dependence of chloroquine block implied that the binding site was located with ...[more]