Ontology highlight
ABSTRACT:
SUBMITTER: Lee SJ
PROVIDER: S-EPMC3868208 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lee Sun-Joo SJ Wang Shizhen S Borschel William W Heyman Sarah S Gyore Jacob J Nichols Colin G CG
Nature communications 20130101
Inwardly rectifying potassium (Kir) channels regulate multiple tissues. All Kir channels require interaction of phosphatidyl-4,5-bisphosphate (PIP2) at a crystallographically identified binding site, but an additional nonspecific secondary anionic phospholipid (PL(-)) is required to generate high PIP2 sensitivity of Kir2 channel gating. The PL(-)-binding site and mechanism are yet to be elucidated. Here we report docking simulations that identify a putative PL(-)-binding site, adjacent to the PI ...[more]