Ontology highlight
ABSTRACT:
SUBMITTER: Dunleavy EM
PROVIDER: S-EPMC2193228 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Molecular cell 20071201 6
A defining feature of centromeres is the presence of the histone H3 variant CENP-A(Cnp1). It is not known how CENP-A(Cnp1) is specifically delivered to, and assembled into, centromeric chromatin. Through a screen for factors involved in kinetochore integrity in fission yeast, we identified Sim3. Sim3 is homologous to known histone binding proteins NASP(Human) and N1/N2(Xenopus) and aligns with Hif1(S. cerevisiae), defining the SHNi-TPR family. Sim3 is distributed throughout the nucleoplasm, yet ...[more]