LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
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ABSTRACT:
SUBMITTER: Brdickova N
PROVIDER: S-EPMC2194115 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
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LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
Brdicková Nadezda N Brdicka Tomás T Angelisová Pavla P Horváth Ondrej O Spicka Jiri J Hilgert Ivan I Paces Jan J Simeoni Luca L Kliche Stefanie S Merten Camilla C Schraven Burkhart B Horejsí Václav V
The Journal of experimental medicine 20031110 10
Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, incr ...[more]
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