Ontology highlight
ABSTRACT:
SUBMITTER: Nagafuku M
PROVIDER: S-EPMC3277553 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Nagafuku Masakazu M Okuyama Kaori K Onimaru Yuri Y Suzuki Akemi A Odagiri Yuta Y Yamashita Tadashi T Iwasaki Katsunori K Fujiwara Michihiro M Takayanagi Motoaki M Ohno Isao I Inokuchi Jin-ichi J
Proceedings of the National Academy of Sciences of the United States of America 20120117 6
Initial events of T-cell activation involve movement of the T-cell receptor into lipid rafts. Gangliosides are major components of lipid rafts. While investigating T-cell activation in ganglioside-deficient mice, we observed that CD4(+) and CD8(+) T cells required different ganglioside subsets for activation. Activation of CD4(+) T cells from GM3 synthase-null mice, deficient in GM3-derived gangliosides, is severely compromised, whereas CD8(+) T-cell activation is normal. Conversely, in cells fr ...[more]