Ontology highlight
ABSTRACT:
SUBMITTER: Chang YC
PROVIDER: S-EPMC2195848 | biostudies-literature | 2000 Mar
REPOSITORIES: biostudies-literature
Chang Y C YC Wickes B L BL Miller G F GF Penoyer L A LA Kwon-Chung K J KJ
The Journal of experimental medicine 20000301 5
The Cryptococcus neoformans STE12alpha gene, a homologue of Saccharomyces cerevisiae STE12, exists only in mating type (MAT)alpha cells. In S. cerevisiae, STE12 was required for mating and filament formation. In C. neoformans, haploid fruiting on filament agar required STE12alpha. The ability to form hyphae, however, was not affected by deletion of STE12alpha when convergently growing MATa strains were present. Furthermore, ste12alpha disruptants were fertile when mated with MATa strains, albeit ...[more]