A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans.
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ABSTRACT:
SUBMITTER: Paes HC
PROVIDER: S-EPMC6243373 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
A Wor1-Like Transcription Factor Is Essential for Virulence of <i>Cryptococcus neoformans</i>.
Paes Hugo Costa HC Derengowski Lorena da Silveira LDS Peconick Luisa Defranco Ferreira LDF Albuquerque Patrícia P Pappas Georgios Joannis GJ Nicola André Moraes AM Silva Fabiana Brandão Alves FBA Vallim Marcelo Afonso MA Alspaugh J Andrew JA Felipe Maria Sueli Soares MSS Fernandes Larissa L
Frontiers in cellular and infection microbiology 20181113
Gti1/Pac2 transcription factors occur exclusively in fungi and their roles vary according to species, including regulating morphological transition and virulence, mating and secondary metabolism. Many of these functions are important for fungal pathogenesis. We therefore hypothesized that one of the two proteins of this family in <i>Cryptococcus neoformans</i>, a major pathogen of humans, would also control virulence-associated cellular processes. Elimination of this protein in <i>C. neoformans< ...[more]
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