Ontology highlight
ABSTRACT:
SUBMITTER: Brdicka T
PROVIDER: S-EPMC2196071 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Brdicka Tomás T Imrich Martin M Angelisová Pavla P Brdicková Nadezda N Horváth Ondrej O Spicka Jirí J Hilgert Ivan I Lusková Petra P Dráber Petr P Novák Petr P Engels Niklas N Wienands Jürgen J Simeoni Luca L Osterreicher Jan J Aguado Enrique E Malissen Marie M Schraven Burkhart B Horejsí Václav V
The Journal of experimental medicine 20021201 12
A key molecule necessary for activation of T lymphocytes through their antigen-specific T cell receptor (TCR) is the transmembrane adaptor protein LAT (linker for activation of T cells). Upon TCR engagement, LAT becomes rapidly tyrosine phosphorylated and then serves as a scaffold organizing a multicomponent complex that is indispensable for induction of further downstream steps of the signaling cascade. Here we describe the identification and preliminary characterization of a novel transmembran ...[more]