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Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction.

ABSTRACT: A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reactions under solvent-free conditions affording acyl benzothiophenes in good overall yields.

SUBMITTER: Pal S

PROVIDER: S-EPMC2200667 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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Transition-metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction.

Pal Sarbani S Khan Mohammad Ashrafuddin MA Bindu P P Dubey P K PK

Beilstein journal of organic chemistry 20071025

A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been described via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reactions under solvent-free conditions affording acyl benzothiophenes in good overall yields. ...[more]

PMID: 17961232

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