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Selective synthesis of thioethers in the presence of a transition-metal-free solid Lewis acid.

ABSTRACT: The synthesis of thioethers starting from alcohols and thiols in the presence of amorphous solid acid catalysts is reported. A silica alumina catalyst with a very low content in alumina gave excellent results in terms of both activity and selectivity also under solvent-free conditions. The reaction rate follows the electron density of the carbinol atom in the substrate alcohol and yields up to 99% and can be obtained for a wide range of substrates under mild reaction conditions.

SUBMITTER: Santoro F

PROVIDER: S-EPMC5238612 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Selective synthesis of thioethers in the presence of a transition-metal-free solid Lewis acid.

Santoro Federica F Mariani Matteo M Zaccheria Federica F Psaro Rinaldo R Ravasio Nicoletta N

Beilstein journal of organic chemistry 20161206

The synthesis of thioethers starting from alcohols and thiols in the presence of amorphous solid acid catalysts is reported. A silica alumina catalyst with a very low content in alumina gave excellent results in terms of both activity and selectivity also under solvent-free conditions. The reaction rate follows the electron density of the carbinol atom in the substrate alcohol and yields up to 99% and can be obtained for a wide range of substrates under mild reaction conditions. ...[more]

PMID: 28144333

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