Ontology highlight
ABSTRACT:
SUBMITTER: Ross MD
PROVIDER: S-EPMC2203212 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Ross Michael D MD Martinka Scott S Mukherjee Amitava A Sedor John R JR Vinson Charles C Bruggeman Leslie A LA
Developmental dynamics : an official publication of the American Association of Anatomists 20061101 11
Math6 is a tissue-restricted member of the Atonal family of basic helix-loop-helix (bHLH) transcription factors and has been implicated in specification and differentiation of cell lineages in the brain. We identify here Math6 as a podocyte-expressed bHLH protein that was down-regulated in human immunodeficiency virus-associated nephropathy (HIVAN); a collapsing glomerulopathy characterized by podocyte dedifferentiation. Early in metanephric development, Math6 was expressed in metanephric mesenc ...[more]