Ontology highlight
ABSTRACT:
SUBMITTER: Menetrey J
PROVIDER: S-EPMC2206119 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Ménétrey Julie J Llinas Paola P Cicolari Jérome J Squires Gaëlle G Liu Xiaoyan X Li Anna A Sweeney H Lee HL Houdusse Anne A
The EMBO journal 20071129 1
Myosin VI has an unexpectedly large swing of its lever arm (powerstroke) that optimizes its unique reverse direction movement. The basis for this is an unprecedented rearrangement of the subdomain to which the lever arm is attached, referred to as the converter. It is unclear at what point(s) in the myosin VI ATPase cycle rearrangements in the converter occur, and how this would effect lever arm position. We solved the structure of myosin VI with an ATP analogue (ADP.BeF3) bound in its nucleotid ...[more]