Ontology highlight
ABSTRACT:
SUBMITTER: Beyer TA
PROVIDER: S-EPMC2206132 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Beyer Tobias A TA Xu Weihua W Teupser Daniel D auf dem Keller Ulrich U Bugnon Philippe P Hildt Eberhard E Thiery Joachim J Kan Yuet Wai YW Werner Sabine S
The EMBO journal 20071206 1
The liver is frequently challenged by surgery-induced metabolic overload, viruses or toxins, which induce the formation of reactive oxygen species. To determine the effect of oxidative stress on liver regeneration and to identify the underlying signaling pathways, we studied liver repair in mice lacking the Nrf2 transcription factor. In these animals, expression of several cytoprotective enzymes was reduced in hepatocytes, resulting in oxidative stress. After partial hepatectomy, liver regenerat ...[more]