Ontology highlight
ABSTRACT:
SUBMITTER: Reno CM
PROVIDER: S-EPMC5319720 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Reno Candace M CM Puente Erwin C EC Sheng Zhenyu Z Daphna-Iken Dorit D Bree Adam J AJ Routh Vanessa H VH Kahn Barbara B BB Fisher Simon J SJ
Diabetes 20161017 3
GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis. However, the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized. To assess its importance, a selective knockout of brain GLUT4 (BG4KO) was generated by crossing Nestin-Cre mice with GLUT4-floxed mice. BG4KO mice had a 99% reduction in GLUT4 protein expression throughout the brain. Despite normal feeding and fasting glycemia, BG4KO mice were glucose intolerant, demonstra ...[more]