Ontology highlight
ABSTRACT:
SUBMITTER: Van Lanen SG
PROVIDER: S-EPMC2206564 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Van Lanen Steven G SG Lin Shuangjun S Shen Ben B
Proceedings of the National Academy of Sciences of the United States of America 20080108 2
C-1027 is an enediyne antitumor antibiotic composed of four distinct moieties: an enediyne core, a deoxy aminosugar, a beta-amino acid, and a benzoxazolinate moiety. We now show that the benzoxazolinate moiety is derived from chorismate by the sequential action of two enzymes-SgcD, a 2-amino-2-deoxyisochorismate (ADIC) synthase and SgcG, an iron-sulfur, FMN-dependent ADIC dehydrogenase-to generate 3-enolpyruvoylanthranilate (OPA), a new intermediate in chorismate metabolism. The functional eluci ...[more]