Ontology highlight
ABSTRACT:
SUBMITTER: Van Lanen SG
PROVIDER: S-EPMC2767520 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Van Lanen Steven G SG Lin Shuangjun S Horsman Geoff P GP Shen Ben B
FEMS microbiology letters 20090927 2
The C-1027 enediyne antitumor antibiotic from Streptomyces globisporus possesses an (S)-3-chloro-5-hydroxy-beta-tyrosine moiety, the chloro- and hydroxy-substituents of which are installed by a flavin-dependent halogenase SgcC3 and monooxygenase SgcC, respectively. Interestingly, a single flavin reductase, SgcE6, can provide reduced flavin to both enzymes. Bioinformatics analysis reveals that, similar to other flavin reductases involved in natural product biosynthesis, SgcE6 belongs to the HpaC- ...[more]