Ontology highlight
ABSTRACT:
SUBMITTER: Yan X
PROVIDER: S-EPMC6261254 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Journal of natural products 20180118 3
The potent cytotoxicity and unique mode of action make the enediyne antitumor antibiotic C-1027 an exquisite drug candidate for anticancer chemotherapy. However, clinical development of C-1027 has been hampered by its low titer from the original producer Streptomyces globisporus C-1027. Here we report three new C-1027 alternative producers, Streptomyces sp. CB00657, CB02329, and CB03608, from The Scripps Research Institute actinomycetes strain collection. Together with the previously disclosed S ...[more]