Ontology highlight
ABSTRACT:
SUBMITTER: Liedtke W
PROVIDER: S-EPMC2211528 | biostudies-literature | 2000 Oct
REPOSITORIES: biostudies-literature
Liedtke W W Choe Y Y Martí-Renom M A MA Bell A M AM Denis C S CS Sali A A Hudspeth A J AJ Friedman J M JM Heller S S
Cell 20001001 3
The detection of osmotic stimuli is essential for all organisms, yet few osmoreceptive proteins are known, none of them in vertebrates. By employing a candidate-gene approach based on genes encoding members of the TRP superfamily of ion channels, we cloned cDNAs encoding the vanilloid receptor-related osmotically activated channel (VR-OAC) from the rat, mouse, human, and chicken. This novel cation-selective channel is gated by exposure to hypotonicity within the physiological range. In the centr ...[more]