Ontology highlight
ABSTRACT:
SUBMITTER: Sung HH
PROVIDER: S-EPMC2211895 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20040412 8
Decoy receptor 3 (DCR3) halts both Fas ligand- and LIGHT-induced cell deaths, which are required for pancreatic beta cell damage in autoimmune diabetes. To directly investigate the therapeutic potential of DCR3 in preventing this disease, we generated transgenic nonobese diabetic mice, which overexpressed DCR3 in beta cells. Transgenic DCR3 protected mice from autoimmune and cyclophosphamide-induced diabetes in a dose-dependent manner and significantly reduced the severity of insulitis. Local ex ...[more]