Ontology highlight
ABSTRACT:
SUBMITTER: Zaldumbide A
PROVIDER: S-EPMC3734667 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Zaldumbide Arnaud A Alkemade Gonnie G Carlotti Françoise F Nikolic Tatjana T Abreu Joana Rf JR Engelse Marten A MA Skowera Anja A de Koning Eelco J EJ Peakman Mark M Roep Bart O BO Hoeben Rob C RC Wiertz Emmanuel Jhj EJ
Molecular therapy : the journal of the American Society of Gene Therapy 20130521 8
Islet transplantation is a promising therapy for type 1 diabetes, but graft function and survival are compromised by recurrent islet autoimmunity. Immunoprotection of islets will be required to improve clinical outcome. We engineered human β cells to express herpesvirus-encoded immune-evasion proteins, "immunevasins." The capacity of immunevasins to protect β cells from autoreactive T-cell killing was evaluated in vitro and in vivo in humanized mice. Lentiviral vectors were used for efficient ge ...[more]