Ontology highlight
ABSTRACT:
SUBMITTER: Metelitsa LS
PROVIDER: S-EPMC2211904 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20040501 9
CD1d-restricted Valpha24-Jalpha18-invariant natural killer T cells (iNKTs) are potentially important in tumor immunity. However, little is known about their localization to tumors. We analyzed 98 untreated primary neuroblastomas from patients with metastatic disease (stage 4) for tumor-infiltrating iNKTs using TaqMan((R)) reverse transcription polymerase chain reaction and immunofluorescent microscopy. 52 tumors (53%) contained iNKTs, and oligonucleotide microarray analysis of the iNKT(+) and iN ...[more]