CAR-Expressing Natural Killer Cells for Cancer Retargeting.
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ABSTRACT:
SUBMITTER: Kloess S
PROVIDER: S-EPMC6558329 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
CAR-Expressing Natural Killer Cells for Cancer Retargeting.
Kloess Stephan S Kretschmer Anna A Stahl Lilly L Fricke Stephan S Koehl Ulrike U
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 20190205 1
Since the approval in 2017 and the outstanding success of Kymriah® and Yescarta®, the number of clinical trials investigating the safety and efficacy of chimeric antigen receptor-modified autologous T cells has been constantly rising. Currently, more than 200 clinical trials are listed on clinicaltrial.gov. In contrast to CAR-T cells, natural killer (NK) cells can be used from allogeneic donors as an "off the shelf product" and provide alternative candidates for cancer retargeting. This review s ...[more]
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