Ontology highlight
ABSTRACT:
SUBMITTER: Weber JR
PROVIDER: S-EPMC2212210 | biostudies-literature | 1998 Apr
REPOSITORIES: biostudies-literature
Weber J R JR Orstavik S S Torgersen K M KM Danbolt N C NC Berg S F SF Ryan J C JC Taskén K K Imboden J B JB Vaage J T JT
The Journal of experimental medicine 19980401 7
Activation of T and natural killer (NK) cells leads to the tyrosine phosphorylation of pp36 and to its association with several signaling molecules, including phospholipase Cgamma-1 and Grb2. Microsequencing of peptides derived from purified rat pp36 protein led to the cloning, in rat and man, of cDNA encoding a T- and NK cell-specific protein with several putative Src homology 2 domain-binding motifs. A rabbit antiserum directed against a peptide sequence from the cloned rat molecule recognized ...[more]