Ontology highlight
ABSTRACT:
SUBMITTER: Baumgartner M
PROVIDER: S-EPMC2223407 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Baumgartner Martin M Radziwill Gerald G Lorger Mihaela M Weiss Andreas A Moelling Karin K
Molecular and cellular biology 20071126 2
c-Src tyrosine kinase controls proliferation, cell adhesion, and cell migration and is highly regulated. A novel regulatory mechanism to control c-Src function that has recently been identified involves the C-terminal amino acid sequence Gly-Glu-Asn-Leu (GENL) of c-Src as ligand for PDZ domains. Herein, we determined the biological relevance of this c-Src regulation in human breast epithelial cells. The intact GENL sequence maintained c-Src in an inactive state in starved cells and restricted c- ...[more]