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Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?

ABSTRACT: Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.

SUBMITTER: Matrat S 

PROVIDER: S-EPMC2224767 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature

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Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?

Matrat Stéphanie S   Cambau Emmanuelle E   Jarlier Vincent V   Aubry Alexandra A  

Antimicrobial agents and chemotherapy 20071210 2

Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not. ...[more]

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