Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Rubio JJ
PROVIDER: S-EPMC2228885 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Lopez-Rubio Jose Juan JJ Gontijo Alisson M AM Nunes Marta C MC Issar Neha N Hernandez Rivas Rosaura R Scherf Artur A
Molecular microbiology 20071119 6
In the human malaria parasite Plasmodium falciparum antigenic variation facilitates long-term chronic infection of the host. This is achieved by sequential expression of a single member of the 60-member var family. Here we show that the 5' flanking region nucleates epigenetic events strongly linked to the maintenance of mono-allelic var gene expression pattern during parasite proliferation. Tri- and dimethylation of histone H3 lysine 4 peak in the 5' upstream region of transcribed var and during ...[more]