Ontology highlight
ABSTRACT:
SUBMITTER: Pagel JM
PROVIDER: S-EPMC2234059 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Blood 20071127 4
We describe the use of pretargeted radioimmunotherapy (PRIT) using an anti-murine CD45 antibody-streptavidin (SA) conjugate followed by radiobiotin to deliver radiation selectively to murine hematolymphoid tissues, which may potentially augment the efficacy and decrease the toxicity of radioimmunotherapy for disseminated murine leukemia. Biodistribution and therapeutic results demonstrated high target organ to nontarget organ ratios of radioactivity and significant long-term survival in leukemic ...[more]