Ontology highlight
ABSTRACT:
SUBMITTER: Rigo V
PROVIDER: S-EPMC5656588 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Rigo Valentina V Emionite Laura L Daga Antonio A Astigiano Simonetta S Corrias Maria Valeria MV Quintarelli Concetta C Locatelli Franco F Ferrini Silvano S Croce Michela M
Scientific reports 20171025 1
Anti-PD-1 or anti-PD-L1 blocking monoclonal antibodies (mAbs) have shown potent anti-tumor effects in adult cancer patients and clinical studies have recently been started in pediatric cancers, including high-risk/relapsing neuroblastoma (NB). Therefore, we studied the effects of anti-PD-1/PD-L1 mAbs in two syngeneic models of disseminated NB generated by the injection of either Neuro2a or NXS2 cells, which express PD-L1. In addition, we tested the combination of these agents with the immune-enh ...[more]