Ontology highlight
ABSTRACT:
SUBMITTER: Kirilyuk A
PROVIDER: S-EPMC2241872 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Kirilyuk Alexander A Tolstonog Genrich V GV Damert Annette A Held Ulrike U Hahn Silvia S Löwer Roswitha R Buschmann Christian C Horn Axel V AV Traub Peter P Schumann Gerald G GG
Nucleic acids research 20071210 2
LINE-1 (L1) is a highly successful autonomous non-LTR retrotransposon and a major force shaping mammalian genomes. Although there are about 600 000 L1 copies covering 23% of the rat genome, full-length rat L1s (L1Rn) with intact open reading frames (ORFs) representing functional master copies for retrotransposition have not been identified yet. In conjunction with studies to elucidate the role of L1 retrotransposons in tumorigenesis, we isolated and characterized 10 different cDNAs from transcri ...[more]