Ontology highlight
ABSTRACT:
SUBMITTER: Baker ML
PROVIDER: S-EPMC3107677 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Baker Matthew L ML Baker Mariah R MR Hryc Corey F CF Dimaio Frank F
Methods in enzymology 20100101
Today, electron cryomicroscopy (cryo-EM) can routinely achieve subnanometer resolutions of complex macromolecular assemblies. From a density map, one can extract key structural and functional information using a variety of computational analysis tools. At subnanometer resolution, these tools make it possible to isolate individual subunits, identify secondary structures, and accurately fit atomic models. With several cryo-EM studies achieving resolutions beyond 5Å, computational modeling and feat ...[more]