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X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.

ABSTRACT: Human carbonic anhydrases (CAs) are well studied targets for the development of inhibitors for pharmaceutical applications. The crystal structure of human CA II has been determined in complex with two CA inhibitors (CAIs) containing conventional sulfonamide and thiadiazole moieties separated by a -CF2- or -CHNH2- spacer group. The structures presented here reveal that these spacer groups allow novel binding modes for the thiadiazole moiety compared with conventional CAIs.

SUBMITTER: Fisher SZ

PROVIDER: S-EPMC2242956 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

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X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.

Fisher S Zoë SZ Govindasamy Lakshmanan L Boyle Nicholas N Agbandje-McKenna Mavis M Silverman David N DN Blackburn G Michael GM McKenna Robert R

Acta crystallographica. Section F, Structural biology and crystallization communications 20060610 Pt 7

Human carbonic anhydrases (CAs) are well studied targets for the development of inhibitors for pharmaceutical applications. The crystal structure of human CA II has been determined in complex with two CA inhibitors (CAIs) containing conventional sulfonamide and thiadiazole moieties separated by a -CF2- or -CHNH2- spacer group. The structures presented here reveal that these spacer groups allow novel binding modes for the thiadiazole moiety compared with conventional CAIs. ...[more]

PMID: 16820676

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