Ontology highlight
ABSTRACT:
SUBMITTER: Supuran CT
PROVIDER: S-EPMC6009921 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Journal of enzyme inhibition and medicinal chemistry 20181201 1
A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type PhX (X = COOH, CONH<sub>2</sub>, CONHNH<sub>2</sub>, CONHOH, CONHOMe), and the corresponding derivatives with sulphur(VI)-based ZBGs (X = SO<sub>3</sub>H, SO<sub>2</sub>NH<sub>2</sub>, SO<sub>2</sub>NHNH<sub>2</sub>, SO<sub>2</sub>NHOH, SO<sub>2</sub>NHOMe) were tested as inhibitors of all mammalian isoforms of carbonic anhydrase (CA, EC 4.2.1.1), CA I-XV. Three factors connected with the ZBG influenced the eff ...[more]