Ontology highlight
ABSTRACT:
SUBMITTER: Jennings BH
PROVIDER: S-EPMC2246631 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Jennings Barbara H BH Wainwright S Mark SM Ish-Horowicz David D
EMBO reports 20071123 1
The Groucho (Gro)/transducin-like enhancer of split family of transcriptional corepressors are implicated in many signalling pathways that are important in development and disease, including those mediated by Notch, Wnt and Hedgehog. Here, we describe a genetic screen in Drosophila that yielded 50 new gro alleles, including the first protein-null allele, and has two mutations in the conserved Q oligomerization domain that have been proposed to have an essential role in corepressor activity. One ...[more]