Growth hormone enhances thymic function in HIV-1-infected adults.
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ABSTRACT:
SUBMITTER: Napolitano LA
PROVIDER: S-EPMC2248326 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Growth hormone enhances thymic function in HIV-1-infected adults.
Napolitano Laura A LA Schmidt Diane D Gotway Michael B MB Ameli Niloufar N Filbert Erin L EL Ng Myra M MM Clor Julie L JL Epling Lorrie L Sinclair Elizabeth E Baum Paul D PD Li Kai K Killian Marisela Lua ML Bacchetti Peter P McCune Joseph M JM
The Journal of clinical investigation 20080301 3
Growth hormone (GH) is an underappreciated but important regulator of T cell development that can reverse age-related declines in thymopoiesis in rodents. Here, we report findings of a prospective randomized study examining the effects of GH on the immune system of HIV-1-infected adults. GH treatment was associated with increased thymic mass. In addition, GH treatment enhanced thymic output, as measured by both the frequency of T cell receptor rearrangement excision circles in circulating T cell ...[more]
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