Conserved water molecules stabilize the Omega-loop in class A beta-lactamases.
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ABSTRACT:
SUBMITTER: Bos F
PROVIDER: S-EPMC2258531 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Conserved water molecules stabilize the Omega-loop in class A beta-lactamases.
Antimicrobial agents and chemotherapy 20080114 3
A set of 49 high-resolution (<or=2.2 A) structures of the TEM, SHV, and CTX-M class A beta-lactamase families was systematically analyzed to investigate the role of conserved water molecules in the stabilization of the Omega-loop. Overall, 13 water molecules were found to be conserved in at least 45 structures, including two water positions which were found to be conserved in all structures. Of the 13 conserved water molecules, 6 are located at the Omega-loop, forming a dense cluster with hydrog ...[more]
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