A Standard Numbering Scheme for Class C ?-Lactamases.
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ABSTRACT:
SUBMITTER: Mack AR
PROVIDER: S-EPMC7038296 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
A Standard Numbering Scheme for Class C β-Lactamases.
Mack Andrew R AR Barnes Melissa D MD Taracila Magdalena A MA Hujer Andrea M AM Hujer Kristine M KM Cabot Gabriel G Feldgarden Michael M Haft Daniel H DH Klimke William W van den Akker Focco F Vila Alejandro J AJ Smania Andrea A Haider Shozeb S Papp-Wallace Krisztina M KM Bradford Patricia A PA Rossolini Gian Maria GM Docquier Jean-Denis JD Frère Jean-Marie JM Galleni Moreno M Hanson Nancy D ND Oliver Antonio A Plésiat Patrick P Poirel Laurent L Nordmann Patrice P Palzkill Timothy G TG Jacoby George A GA Bush Karen K Bonomo Robert A RA
Antimicrobial agents and chemotherapy 20200221 3
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser<sup>64</sup>, Lys<sup>67</sup>, Tyr<sup>150</sup>, and Lys<sup>315</sup>), is adaptable to new variants or enzymes yet to be discovered an ...[more]
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