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Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria.


ABSTRACT: β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional β-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional β-lactamases are widespread in nature; these findings also raise concern that bifunctional β-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms.

SUBMITTER: Silveira MC 

PROVIDER: S-EPMC5967600 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria.

Silveira Melise Chaves MC   Catanho Marcos M   Miranda Antônio Basílio de AB  

Memorias do Instituto Oswaldo Cruz 20180528 8


β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of  ...[more]

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