Substrate specificity and screening of the integral membrane protease Pla.
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ABSTRACT:
SUBMITTER: Agarkov A
PROVIDER: S-EPMC2263006 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
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Substrate specificity and screening of the integral membrane protease Pla.
Agarkov Anton A Chauhan Sadhana S Lory Pedro J PJ Gilbertson Scott R SR Motin Vladimir L VL
Bioorganic & medicinal chemistry letters 20071012 1
This paper reports a study to find small peptide substrates for the important virulence factor of Yersinia pestis, plasminogen activator, Pla. The method used to find small substrates for this protease is reported along with studies examining the ability of these peptides to inhibit activity of the enzyme. Through the use of parallel synthesis and positional scanning, small tripeptides were identified that are viable substrates for the protease. ...[more]
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