Ontology highlight
ABSTRACT:
SUBMITTER: Pryor EE
PROVIDER: S-EPMC4136949 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130301 6127
Posttranslational lipidation provides critical modulation of the functions of some proteins. Isoprenoids (i.e., farnesyl or geranylgeranyl groups) are attached to cysteine residues in proteins containing C-terminal CAAX sequence motifs (where A is an aliphatic residue and X is any residue). Isoprenylation is followed by cleavage of the AAX amino acid residues and, in some cases, by additional proteolytic cuts. We determined the crystal structure of the CAAX protease Ste24p, a zinc metalloproteas ...[more]