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The effect of immune selection on the structure of the meningococcal opa protein repertoire.

ABSTRACT: The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles. We analysed the Opa repertoire structure in a large, well-characterised collection of asymptomatically carried meningococci. Our data show an association between Opa repertoire and meningococcal lineages similar to that observed previously for meningococci isolated from cases of invasive disease. Furthermore, these Opa repertoires exhibit discrete, non-overlapping structure at a population level, and yet low within-repertoire diversity. These data are consistent with the predictions of a mathematical model of strong immune selection upon a system where identical alleles may occupy different loci.

SUBMITTER: Callaghan MJ

PROVIDER: S-EPMC2265424 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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The effect of immune selection on the structure of the meningococcal opa protein repertoire.

Callaghan Martin J MJ Buckee Caroline O CO Jolley Keith A KA Kriz Paula P Maiden Martin C J MC Gupta Sunetra S

PLoS pathogens 20080314 3

The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles. We analysed the Opa repertoire structure in a large, well-characterised collection of asymptomatically carried meningococci. Our data show an association between Opa repertoire and ...[more]

PMID: 18369470

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