Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC4538435 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Liu Ping P Hu Zhiyong Z DuBois Byron G BG Moyes Christopher R CR Hunter David N DN Zhu Cheng C Kar Nam Fung NF Zhu Yuping Y Garfunkle Joie J Kang Ling L Chicchi Gary G Ehrhardt Anka A Woods Andrea A Seo Toru T Woods Morgan M van Heek Margaret M Dingley Karen H KH Pang Jianmei J Salituro Gino M GM Powell Joyce J Terebetski Jenna L JL Hornak Viktor V Campeau Louis-Charles LC Lamberson Joe J Ujjainwalla Fez F Miller Michael M Stamford Andrew A Wood Harold B HB Kowalski Timothy T Nargund Ravi P RP Edmondson Scott D SD
ACS medicinal chemistry letters 20150710 8
We report herein the design and synthesis of a series of potent and selective GPR119 agonists. Our objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analogue (1), medicinal chemistry efforts directed toward reducing half-life and increasing solubility led to the synthesis of a series of benzyloxy analogues. Compound 28 was chosen for further profiling because of its favorable physicochemical prop ...[more]