Ontology highlight
ABSTRACT:
SUBMITTER: Nandakumar J
PROVIDER: S-EPMC3289999 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Nandakumar Jayakrishnan J Schwer Beate B Schaffrath Raffael R Shuman Stewart S
Molecular cell 20080701 2
RNA healing and sealing enzymes drive informational and stress response pathways entailing repair of programmed 2',3' cyclic PO(4)/5'-OH breaks. Fungal, plant, and phage tRNA ligases use different strategies to discriminate the purposefully broken ends of the anticodon loop. Whereas phage ligase recognizes the tRNA fold, yeast and plant ligases do not and are instead hardwired to seal only the tRNA 3'-OH, 2'-PO(4) ends formed by healing of a cyclic phosphate. tRNA anticodon damage inflicted by s ...[more]