Ontology highlight
ABSTRACT:
SUBMITTER: Huuskonen KH
PROVIDER: S-EPMC2276816 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Mediators of inflammation 20080101
Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the -765G-->C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level. The Helsinki sudden death study autopsy material (n = 300) comprised of Finnish men who died suddenly. The area of atherosclerotic lesions in the coronary arteries was quantit ...[more]