Ontology highlight
ABSTRACT:
SUBMITTER: Blank HM
PROVIDER: S-EPMC2289842 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Blank Heidi M HM Li Chonghua C Mueller John E JE Bogomolnaya Lydia M LM Bryk Mary M Polymenis Michael M
PLoS genetics 20080411 4
Coordination between cellular metabolism and DNA replication determines when cells initiate division. It has been assumed that metabolism only plays a permissive role in cell division. While blocking metabolism arrests cell division, it is not known whether an up-regulation of metabolic reactions accelerates cell cycle transitions. Here, we show that increasing the amount of mitochondrial DNA accelerates overall cell proliferation and promotes nuclear DNA replication, in a nutrient-dependent man ...[more]