Ontology highlight
ABSTRACT:
SUBMITTER: Rosas-Acosta G
PROVIDER: S-EPMC2292128 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Rosas-Acosta Germán G Wilson Van G VG
Virology 20080221 1
Recent studies have demonstrated nuclear export by papillomavirus E1 proteins, but the requisite export sequence(s) for bovine papillomavirus (BPV) E1 were not defined. In this report we identify three functional nuclear export sequences (NES) present in BPV E1, with NES2 being the strongest in reporter assays. Nuclear localization of BPV1 E1 was modulated by over- or under-expression of CRM1, the major cellular exportin, and export was strongly reduced by the CRM1 inhibitor, Leptomycin B, indic ...[more]