Ontology highlight
ABSTRACT:
SUBMITTER: Campbell CS
PROVIDER: S-EPMC4014439 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Campbell Christopher S CS Hombauer Hans H Srivatsan Anjana A Bowen Nikki N Gries Kerstin K Desai Arshad A Putnam Christopher D CD Kolodner Richard D RD
PLoS genetics 20140508 5
In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear. Mlh1-Mlh2 formed foci that often colocalized with and had a longer lifetime than Mlh1-Pms1 foci. Mlh1-Mlh2 foci were similar to Mlh1-Pms1 foci: they required mispair recognition by Msh2-Msh6, increased in response to increased mispairs or downstream defects ...[more]