Ontology highlight
ABSTRACT:
SUBMITTER: Dahal BK
PROVIDER: S-EPMC5673234 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Dahal Basanta K BK Kadyrova Lyudmila Y LY Delfino Kristin R KR Rogozin Igor B IB Gujar Vaibhavi V Lobachev Kirill S KS Kadyrov Farid A FA
PLoS genetics 20171025 10
Heterochromatin contains a significant part of nuclear DNA. Little is known about the mechanisms that govern heterochromatic DNA stability. We show here that in the yeast Saccharomyces cerevisiae (i) DNA mismatch repair (MMR) is required for the maintenance of heterochromatic DNA stability, (ii) MutLα (Mlh1-Pms1 heterodimer), MutSα (Msh2-Msh6 heterodimer), MutSβ (Msh2-Msh3 heterodimer), and Exo1 are involved in MMR at heterochromatin, (iii) Exo1-independent MMR at heterochromatin frequently lead ...[more]